ORGANIC CHEMISTRY II

The course aims to provide students with a more in-depth training in Organic Chemistry from the first basic course, particularly with regard to nomenclature, chemical properties and reactivity of multifunctional compounds; the main classes of organic compounds of biological significance: carbohydrates, amino acids and peptides, lipids; the major heterocyclic systems. Students will gain further knowledge on advanced organic synthesis reactions, learning to develop simple synthetic sequences of polyfunctional organic compounds and to apply the principles of modern synthetic strategies for disconnection approaches, formation of carbon-carbon bonds, deprotection protection of functional groups.

Properties, preparation methods and reactivity of the main classes of difunctional compounds: diol; idrossicarbonilici compounds (idrossialdeidi, hydroxyketones and hydroxy); carbonyl compounds alpha, beta-unsaturated; dicarbonyl compounds (dicarboxylic acids, beta-ketoesters, beta-diketones). Mechanisms, procedures and potential applications of the main classes of reactions of enolate anions and enamines. Structure and reactivity of the carbonyl compounds a, b-unsaturated. Mechanisms and synthetic applications of nucleophilic aromatic substitution reactions. Structure, properties, methods of synthesis and reactivity of phenols. Properties, methods of preparation and reactivity of: aliphatic and aromatic amines. Aromatic diazonium salts and their utility in organic synthesis. The most commonly utilized in the synthesis of polysubstituted aromatic compounds strategies. Properties, preparation and reactivity of polycondensed aromatic compounds. Properties, methods of preparation and reactivity of the main aromatic heterocyclic systems. synthetic polymers. Properties, stereochemistry and reactivity of monosaccharides and disaccharides and polysaccharides main. Amino acids, peptides and proteins. Lipids. pericyclic reactions.

• B. Botta, Chimica Organica, Ed. Edi.Ermes, Milano (ISBN 9788870513271);
• P. Y. Bruice, Chimica Organica, Ed. EDISES, Napoli;
• J. G. Smith, Chimica Organica, Ed. McGraw-Hill, Milano;
• J. McMurry, Chimica Organica, Ed. PICCIN, Padova.