CHIMICA ORGANICA SUPRAMOLECOLARE E LABORATORIO

Academic Year 2024/2025 - Teacher: GIUSEPPE TRUSSO SFRAZZETTO

Expected Learning Outcomes

The course aims to provide basic information on topics in supramolecular organic chemistry, in particular on the most common practices in the laboratory. The module aims to provide the student with the tools for understanding the formation of supramolecular organic aggregates, with particular reference to organic reactions, and strategies for isolating and characterizing organic supramolecular aggregates. Predicting and deriving the molecular structure of a synthesized supramolecule, or of an unknown supramolecule will be one of the main objectives of the course. Furthermore, one of the main objectives will be to recognize and correctly assemble the laboratory glassware, according to the experience to be carried out. The specific training objectives of the module will be: Knowing how to organize and assemble the laboratory glassware for the realization of a supramolecular synthesis; Knowing how to structurally characterize an organic supramolecule using one or more instrumental techniques; Knowing how to interpret spectroscopic data in order to trace the identity of an organic supramolecule To acquire experience on the methodologies and techniques of non-covalent organic synthesis through the preparation of some products and their structural determination. With reference to the Dublin Descriptors, this course aims to transfer the following transversal skills to the student: Knowledge and understanding: Inductive and deductive reasoning skills; Ability to rationalize and predict the reactivity of organic molecules; Ability to distinguish the different synthesis techniques; Ability to distinguish the different laboratory instruments Ability to apply knowledge: Ability to design a synthetic path suitable for obtaining a precise organic molecule; Ability to foresee the necessary instrumentation for the realization of the synthesis; Ability to identify the optimal reaction conditions for a given reaction. Autonomy of judgment: Critical reasoning skills; Self-assessment of learning through interactions in the classroom with colleagues and with the teacher. Communication skills: Ability to describe in oral and written form, with properties of language and terminological rigor, one of the topics covered, using both power point presentations and the blackboard

Course Structure

The course is structured in two sections: a first part of lectures and a second part of laboratory activities

If the teaching is given in a mixed or remote mode, the necessary changes with respect to what was previously stated may be introduced, in order to respect the program envisaged and reported in the syllabus.

Required Prerequisites

Fundamental of Organic Chemistry

Attendance of Lessons

As established by the didactic regulations of the Course of Studies 

Detailed Course Content

The course is divided into 4 CFU of theoretical lessons and 2 CFU of laboratory activities.

in particular, theoretical lessons:

Non-covalent interactions

P-greek interactions

Hydrophobic effect

Design of supramolecular architectures

Cooperation, pre-organization and complementarity

Characterization of supramolecular systems

Molecular Capsules

Catenani, Rotaxani and Pseudorotaxani

Synthetic strategies of abiotic supramolecular receptors

Synthetic strategies of Molecular Capsules

The laboratory activity:

Structural characterization of organic supramolecules in solution

Applications of supramolecular structures

Laboratory experiences

Textbook Information

- Appunti delle lezioni

- E.V. Anslyn, D.A.Dougherty "Modern Physical Organic Chemistry" University Science Books

- J.M.Lehn "Supramolecular Chemistry" VCH

Course Planning

 SubjectsText References
1non covalent interaction J.M.Lehn "Supramolecular Chemistry" VCH
2pi-pi interactions J.M.Lehn "Supramolecular Chemistry" VCH
3hydrophobic effect J.M.Lehn "Supramolecular Chemistry" VCH
4design of supramolecular structuresnotes of lessons
5characterization of supramolecular structuresnotes of lessons
6supramolecular receptors J.M.Lehn "Supramolecular Chemistry" VCH

Learning Assessment

Learning Assessment Procedures

The exam modality envisaged consists of an oral exam

Verification of learning can also be carried out electronically, should the conditions require it.

Examples of frequently asked questions and / or exercises

1) Self-assembly

2) molecular capsules

3) synthesis of a supramolecule